Item – Theses Canada

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OCLC number
894575752
Link(s) to full text
LAC copy
LAC copy
Author
Liu, Hao Yuan,1961-
Title
Genetic variation of a P-glycoprotein gene in unselected and ivermectin- and moxidectin-selected strains of Haemonchus contortus
Degree
M. Sc. -- McGill University, 1998
Publisher
[Montreal] : McGill University Libraries, [1998]
Description
1 online resource
Notes
Thesis supervisor: Prichard, Roger K. (advisor).
Thesis supervisor: Beech, Robin N. (advisor).
Includes bibliographical references.
Abstract
"Anthelmintics, antiparasitic agents, have been developed as a main weapon to control parasitic nematodes of domestic ruminants. Unfortunately, the intensive use of anthelmintics leads to the development of drug resistance in parasite populations. Anthelmintic resistance has compromised the control of nematode parasites and has become a major problem in many countries of the world. Resistance to the newest anthelmintics such as ivermectin (IVM) and related anthelmintics in Haemonchus contortus in sheep has been developing rapidly in recent years. The development of drug resistance is an evolutionary process that leads to genetic changes in parasite populations in response to drug exposure. However, the mechanism of ivermectin resistance in nematode parasites is unknown. P-glycoprotein (Pgp) has been well documented in mammalian cells as a membrane transporter by actively extruding a variety of structurally and functionally unrelated hydrophobic cytotoxic drugs out of the cell. This study was to determine whether there is an association between specific alleles at the Pgp locus and IVM or moxidectin (MOX) selection in H. contortus, by investigating the genetic variation of the Pgp homologue in unselected and IVM- and MOX-selected strains of H. contortus. (Abstract shortened by UMI.)"--
Other link(s)
digitool.Library.McGill.CA
digitool.library.mcgill.ca:8881
escholarship.mcgill.ca
escholarship.mcgill.ca
Subject
Ivermectin.
Haemonchus contortus.
Sheep Parasites.
Drug resistance.