Item – Theses Canada

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OCLC number
815852661
Link(s) to full text
LAC copy
LAC copy
Author
Tarnauceanu, Alina,1977-
Title
Synthetic studies toward the manzamine alkaloids.
Degree
M. Sc. -- University of New Brunswick, 2008
Publisher
Ottawa : Library and Archives Canada = Bibliothèque et Archives Canada, [2011]
Description
2 microfiches
Notes
Includes bibliographical references.
Abstract
<?Pub Inc> The synthesis of an advanced intermediate toward the ABC cyclic core of the manzamine alkaloids has been successfully achieved in 13 steps. The important steps of this synthesis were a Robinson annulation to obtain the AB bycliclic core, a stereoseleetive hydrogenation to generate the cis-fused hydroisoquinoline and the construction of the key double bond at C3-C4. Additionally, a regioseleetivity study was done in order to clarify if the C-5 substituent of the AB bicyclic core had an influence on the enolate formation.
ISBN
9780494692981
0494692987