Item – Theses Canada

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OCLC number
74028473
Link(s) to full text
LAC copy
LAC copy
Author
Strauss, John,1967-
Title
Molecular genetic investigation of brain-derived neurotrophic factor in childhood-onset mood disorder.
Degree
M. Sc. -- University of Toronto, 2005
Publisher
Ottawa : Library and Archives Canada = Bibliothèque et Archives Canada, [2006]
Description
2 microfiches
Notes
Includes bibliographical references.
Abstract
Childhood-onset mood disorder (COMD) is a condition with pronounced morbidity. Brain-derived neurotrophic factor (BDNF) has antidepressant-like effects at cellular and molecular levels in animals; variants of the BDNF gene have been associated with bipolar disorder. Two BDNF polymorphisms, a dinucleotide repeat, (GT)n, and a single nucleotide polymorphism (SNP), Val66 Met, were genotyped in 99 adults with COMD and matched controls. The BDNF (GT)n marker was associated with COMD (168 bp OR = 3.94, CI = 1.72 to 9.04). Alleles of Va166Met were not associated with COMD. The haplotype val/short contributes to risk. Studies in several species have implicated BDNF and catechol-O-methyltransferase (COMT) in memory. In 63 young adults with a history of COMD, we genotyped three BDNF polymorphisms and the COMT Val108/158 Met SNP. Multivariate analysis of variance (MANOVA) was employed to test hypotheses of association. We found no evidence of association between the two loci and declarative memory phenotypes.
ISBN
0494025344
9780494025345