Item – Theses Canada

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OCLC number
648383440
Link(s) to full text
LAC copy
LAC copy
Author
Li, Xinghan,1982-
Title
The reductive amination chemistry of aziridine aldehydes.
Degree
M. Sc. -- University of Toronto, 2008
Publisher
Ottawa : Library and Archives Canada = Bibliothèque et Archives Canada, [2009]
Description
1 microfiche
Notes
Includes bibliographical references.
Abstract
Amino aldehydes without 'N'-protecting groups are subject to self-condensation, since the amine is able to react with an aldehyde to form an imine/enamine system. As a result, the aldehyde functional group is prematurely destroyed. In order to make it behave as an aldehyde, protection is unavoidable. Even if the unprotected amine and aldehyde groups can co-exist under special conditions, the aldehyde or amine function is unable to react independently. Our recent interest in amphoteric molecules has led to the discovery of stable compounds that contain unprotected amine and aldehyde functionalities. The so-called kinetic amphoterism has been coined in order to describe the co-existence of a secondary amine and aldehyde in such molecules. Amphoteric aziridine aldehydes exhibit different properties from normal aminoaldehydes and have great potential for the construction of peptidomimetic conjugates.
ISBN
9780494388709
0494388706