Item – Theses Canada

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OCLC number
46550291
Link(s) to full text
LAC copy
LAC copy
Author
Basran, Parminder S.(Parminder Singh),1970-
Title
Optimisation of lung cancer treatment.
Degree
M. Sc. -- University of Alberta, 1997
Publisher
Ottawa : National Library of Canada = Bibliothèque nationale du Canada, [1998]
Description
2 microfiches.
Notes
Includes bibliographical references.
Abstract
A general solution for the problem of dose homogeneity in an external photon multi-beam configuration is proposed, where internal and external inhomogeneities are accounted for each beam through strategically constructed compensators, and the effects of the multi-beam arrangement are considered through Sherouse's (1993) gradient vector approach. Through this approach, dose homogeneity within the planning target volumes have been found to be better than 5%, exhibiting sharp dose gradients at the point of beam intersection and conforming tightly to the beam intersection points. The simplicity of this technique renders itself for easy implementation in three dimensional conformal therapies and complicated beam arrangements. The displacements of the lung for several lung cancer patients at the Cross Cancer Institute were taken to estimate the planning target margins specifically allotted for respiration, and also to approximate the clinical implications from irradiating normal lung tissues specifically allotted for this motion. The additional margins, which only include healthy tissue, may be large enough to have negative consequences to the normal lung tissue and thus limit the dose to the tumour. A feasible course of action is to reduce this additional margin through either treating the patient at breath hold, or electronically gating the linac to the tumour's temporal pattern.
ISBN
0612225682
9780612225688