Item – Theses Canada

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OCLC number
267074496
Link(s) to full text
LAC copy
LAC copy
Author
Aultman, Crystal D.,1981-
Title
Chronic aerobic exercise training prevents angiotensin II-mediated endothelial dysfunction in male Sprague-Dawley rats.
Degree
M. Sc. -- University of Waterloo, 2006
Publisher
Ottawa : Library and Archives Canada = Bibliothèque et Archives Canada, [2007]
Description
2 microfiches.
Notes
Includes bibliographical references.
Abstract
A loss of homeostasis in the vasculature results in endothelial dysfunction and this pathological situation is a hallmark of all cardiovascular disease states including essential hypertension. Alterations in the renin-angiotensin system contribute to essential hypertension. Experimentally, angiotensin II (AII) infusion results in hypertension and vascular dysfunction, in part, due to enhanced production of reactive oxygen species and reduced nitric oxide bioavailability. In contrast, chronic aerobic exercise training can improve vasomotor function in health and in various models of hypertension. The purpose of this study was to investigate the effects of chronic exercise training on the development of hypertension and endothelial dysfunction evoked by chronic administration of AII. In conclusion, sedentary but not exercise trained rats exhibit impaired endothelial-dependent dilation in response to chronic AII infusion. Despite improving endothelial vasomotor function, exercise did not lessen the blood pressure response. This study is the first to assess how exercise affects the development of hypertension and vascular dysfunction in this model and subsequently provided evidence to support a role for exercise in preventing AII-mediated endothelial dysfunction. (Abstract shortened by UMI.)
ISBN
9780494171493
0494171499