Item – Theses Canada

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OCLC number
175281965
Link(s) to full text
LAC copy
LAC copy
Author
Lambert-Giroux, Suzanne,1979-
Title
Skeletal muscles lacking Bpag1 crosslinking proteins display aberrant cytoskeletal features.
Degree
M. Sc. -- Laurentian University, 2005
Publisher
Ottawa : Library and Archives Canada = Bibliothèque et Archives Canada, [2006]
Description
2 microfiches
Notes
Includes bibliographical references.
Abstract
Plakin crosslinking proteins have recently emerged as key components of the cytoskeleton. Bullous pemphigoid antigen 1 (Bpag1) is one such protein, identified as the mutated gene responsible for the limb coordination phenotype phenotype observed in 'dystonia musculorum' ('dt') mice. Given that Bpag1b1/2 molecules, which are the predominant isoforms expressed in contractile tissue, harbor binding sites for the primary components of the cytoskeleton (microfilaments (MF), intermediate filaments (IF), microtubules (MT)), it is argued that Bpag1 proteins interact with MFs, IFs and MTs thereby integrating the functions of these cytoskeletal networks. Accordingly, the impact of Bpag1-deficiency on the expression levels of MF, IF and MT subunits, and the subcellular localization of these cytoskeletal elements was assessed in skeletal muscle. (Abstract shortened by UMI.)
ISBN
0494100303
9780494100301