Item – Theses Canada

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OCLC number
1335044707
Link(s) to full text
LAC copy
Author
Panahandeh, Sina.
Title
Characterizing the Association between Brain Morphology and Behavioural Symptomatology in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder.
Degree
M.A.S. -- University of Toronto,, 2019.
Publisher
[Toronto, Ontario] : University of Toronto, 2019
Description
1 online resource
Abstract
Autism spectrum disorder (ASD) and attention decit/hyperactivity disorder (ADHD) are prevalent and highly co-occurring neurodevelopmental disorders. The brain correlates of these disorders remain mostly unknown. This is partly due to the limitations of existing analytic methods in coping with the large within disorder variability and overlap between disorders. To address this challenges, we propose a new method called Bagged-Regression clustering for data-driven discovery of diagnosis-agnostic subgroups that may share brain-behaviour associations. This approach clusters the sample data into K groups, each with its own linear regression function. Using both simulated data and a real-dataset of brain-behaviour associations in ASD and ADHD, we show that the proposed method is able to recover multiple regression lines in the data.
Other link(s)
tspace.library.utoronto.ca
hdl.handle.net
Subject
attention deficit/hyperactivity disorder
autism spectrum disorder
clusterwise regression
regression clustering
social communication