Item – Theses Canada

​
OCLC number
1335042641
Link(s) to full text
LAC copy
Author
Storey, Emily Elizabeth.
Title
A Complete Portable and Low-cost Micro-opto-fluidic Raman Spectroscopic Measurement and Characterization System.
Degree
M.A.S. -- University of Toronto,, 2019.
Publisher
[Toronto, Ontario] : University of Toronto, 2019
Description
1 online resource
Abstract
There is a glaring, unmet demand for a healthcare analysis method which is non-invasive, rapid, portable, and flexible, to provide consistent results for novice and expert users alike. Such a technique would facilitate access to health solutions in rural settlements, where population health can suffer due to limited specialized facilities. Raman spectroscopy of biological fluids is ideal for this task. Widespread adoption requires a robust collection system and a model which can withstand routine spectrum variability, but current methods place the end-user in charge of these remedies. In this thesis we present a point-of-care system for fluidic analysis using Raman which eliminates sample preparation and optimizes analysis, independent of end-user proficiency. A micro-opto-fluidic device greatly enhances the Raman signal, and accompanying machine-learning suite optimizes preprocessing methods to compensate for routine signal variation. We demonstrate performance on artificial human tears and whole-blood, achieving user-independent predictive concentration precision below 500 microMolar.
Other link(s)
tspace.library.utoronto.ca
tspace.library.utoronto.ca
hdl.handle.net
Subject
Biofluid Diagnostics
Machine Learning
Optofluidics
Photonic Crystal Fibers
Principal Component Analysis
Raman Spectroscopy