Item – Theses Canada

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OCLC number
1334671465
Link(s) to full text
LAC copy
Author
Wadji, Fariba Baghai.
Title
Characterization of Abuse Properties of the Anesthetic Propofol Using the Self-administration Paradigm in Rats.
Degree
MAST -- University of Toronto, 2013.
Publisher
[Toronto, Ontario] : University of Toronto, 2013
Description
1 online resource
Abstract
Propofol is a widely in use anesthetic drug. Propofol's abuse liability has been supported by many case reports and a few animal studies. However, propofol's reinforcing properties have not yet been investigated in-depth. In this study, multiple aspects of propofol's abuse-related behaviour were investigated using the drug self-administration model in rats. METHODS: Rats were subjected to propofol self-administration under a fixed ratio 1 (FR1) schedule and different aspects of propofol self-administration behaviour including acquisition, maintenance of the behaviour under a higher ratio schedule, extinction and reinstatement were investigated. RESULTS: Rats acquired propofol self-administration under a FR1 schedule. The acquired behaviour was maintained under a FR2 schedule, showed a modest variation over a range of doses, and was extinguished upon substitution of vehicle for propofol, showing no reinstatement using a range of priming doses of propofol. CONCLUSION: Propofol has abuse potential showing modest reinforcing properties under our experimental conditions.
Other link(s)
tspace.library.utoronto.ca
hdl.handle.net
Subject
propofol self-administration
fixed ratio schedule
substance abuse
acquisition
extinction
reinstatement