Item – Theses Canada

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OCLC number
1334505810
Link(s) to full text
LAC copy
Author
Slavko, Ekaterina.
Title
Synthetic Routes to Well-defined Biodegradable Polymers using Organoboron Catalysts.
Degree
Ph.D. -- University of Toronto, 2019.
Publisher
[Toronto, Ontario] : University of Toronto, 2019
Description
1 online resource
Abstract
Borinic acid catalysis is used as a tool for the synthesis of carbohydrate-derived polymers of biomedical interest. Polyols possessing 3 or 4 hydroxyl groups are subjected to site-selective polymerization without protecting group manipulations. Chapter 1 serves as an introduction describing common biomedical polymers and our approach to their synthesis. In Chapter 2, the synthesis of well-defined linear polyesters derived from glycerol is described as a proof-ofconcept for the translation of borinic acid-catalyzed polyol derivatizations to macromolecular synthesis. In Chapter 3, linear polyesters derived from anomerically protected pyranosides are described, highlighting the scope of the borinic acid-promoted polycondensation. In Chapter 4, structure-property relationships among polyesters derived from monomers with diverse anomeric side-chains are uncovered, demonstrating the versatility of this new monomer class in modulating thermal, physical and degradation behaviours. Finally, concluding remarks are made in Chapter 5, along with a summary of related research directions, including the implementation of borinic acids as a tool for methacrylate monomer synthesis as well as their use in promoting the synthesis of glycerol- and pyranoside-derived polyurethanes.
Other link(s)
tspace.library.utoronto.ca
hdl.handle.net
Subject
carbohydrate
catalysis
polyester