Skip to main content
Skip to "About government"
Language selection
Français
Government of Canada /
Gouvernement du Canada
Search
Search the website
Search
Menu
Main
Menu
Jobs and the workplace
Immigration and citizenship
Travel and tourism
Business and industry
Benefits
Health
Taxes
Environment and natural resources
National security and defence
Culture, history and sport
Policing, justice and emergencies
Transport and infrastructure
Canada and the world
Money and finances
Science and innovation
You are here:
Canada.ca
Library and Archives Canada
Services
Services for galleries, libraries, archives and museums (GLAMs)
Theses Canada
Item – Theses Canada
Page Content
Item – Theses Canada
OCLC number
1033196610
Link(s) to full text
LAC copy
LAC copy
Author
Belo, Cassandra Joy.
Title
The Effect of 17Beta- and 17Alpha-estradiol on Myelination and Remyelination in Cerebellar Slices.
Degree
MAST -- University of Toronto, 2013
Publisher
Toronto : University of Toronto, 2013.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
Multiple sclerosis is thought to be an autoimmune disease that causes lesions and demyelination of axons in the central nervous system. A reduction in relapses is seen in the third trimester of pregnancy when estrogen levels are highest, followed by an increase in relapses in the first three months post-partum when estrogen levels drop. This thesis focuses on the effect of 17beta- and 17alpha-estradiol on myelination and remyelination in cultured rat cerebellar slices. No reproducible effect of 17beta-estradiol on myelination was detected. However, during lysolecithin-induced demyelination it had a possible protective effect in males and females, although it was not statistically significant. During myelination, 100 nM 17alpha-estradiol caused a small but significant decrease in MBP expression in females. During lysolecithin-induced demyelination, it had a possible, but not statistically significant, protective effect in males. Neither 17beta- nor 17alpha-estradiol had a reproducible or significant effect on remyelination in males or females.
Other link(s)
hdl.handle.net
tspace.library.utoronto.ca
Subject
multiple sclerosis.
estrogen.
myelination.
remyelination.
0317.
Date modified:
2022-09-01