Item – Theses Canada

OCLC number
1033196610
Link(s) to full text
LAC copy
LAC copy
Author
Belo, Cassandra Joy.
Title
The Effect of 17Beta- and 17Alpha-estradiol on Myelination and Remyelination in Cerebellar Slices.
Degree
MAST -- University of Toronto, 2013
Publisher
Toronto : University of Toronto, 2013.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
Multiple sclerosis is thought to be an autoimmune disease that causes lesions and demyelination of axons in the central nervous system. A reduction in relapses is seen in the third trimester of pregnancy when estrogen levels are highest, followed by an increase in relapses in the first three months post-partum when estrogen levels drop. This thesis focuses on the effect of 17beta- and 17alpha-estradiol on myelination and remyelination in cultured rat cerebellar slices. No reproducible effect of 17beta-estradiol on myelination was detected. However, during lysolecithin-induced demyelination it had a possible protective effect in males and females, although it was not statistically significant. During myelination, 100 nM 17alpha-estradiol caused a small but significant decrease in MBP expression in females. During lysolecithin-induced demyelination, it had a possible, but not statistically significant, protective effect in males. Neither 17beta- nor 17alpha-estradiol had a reproducible or significant effect on remyelination in males or females.
Other link(s)
hdl.handle.net
tspace.library.utoronto.ca
Subject
multiple sclerosis.
estrogen.
myelination.
remyelination.
0317.