Item – Theses Canada

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OCLC number
1033023596
Link(s) to full text
LAC copy
LAC copy
Author
Gendron, William.
Title
AGE-RELATED WEIGHT LOSS IN THE 5XFAD MOUSE MODEL OF ALZHEIMER'S DISEASE : a BEHAVIOURAL AND HORMONAL ANALYSIS.
Degree
Master of Science -- Dalhousie University, 2015
Publisher
Halifax : Dalhousie University, 2015.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
The 5xFAD mice exhibit weight loss at 9 months of age. We investigated age-related changes in body weight, feeding behaviour, activity levels, feeding-related hormones, and proteins regulating adipogenesis and thermogenesis in female 5xFAD mice and their WT controls. The 5xFAD mice were hypoactive in climbing and rearing (p<0.05), and were frequently still (p<0.05). Differences in food intake and body weight occurred at 9 and 12 months of age, where WT ate and weighed more (p<0.05). The 5xFAD mice had less white adipose tissue (WAT); p<0.05). Expression of leptin mRNA, UCP-2, UCP-1, and HSL were measured in WAT and did not differ between genotypes (p<0.05). Transgenic mice expressed more UCP-1 (p<0.05). At 9 and 12 months of age, the 5xFAD mice ate less, had a lower body weight and were hypoactive. At 12 months of age the 5xFAD mice had less body fat and expressed less leptin, UCP-2, and HSL mRNA.
Other link(s)
hdl.handle.net
DalSpace.library.dal.ca:8080
DalSpace.library.dal.ca
Subject
Alzheimer's disease.
Ageing.
Metabolism.