Item – Theses Canada

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OCLC number
1033004998
Link(s) to full text
LAC copy
Author
Tiwari, Akansha.
Title
Characterizing the Role of Stromal Cell Derived Factor 2 Like-1 (SDF2L1) in Pancreatic [beta]-Cells.
Degree
MAST -- University of Toronto, 2011
Publisher
Toronto : University of Toronto, 2011.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
Type 2 diabetes is characterized by insulin resistance and pancreatic [beta]-cell failure. Insulin resistance leads to increased insulin demand, which can lead to increased proinsulin misfolding in the endoplasmic reticulum (ER). The accumulation of the misfolded proteins in the ER can cause ER stress, which can lead to pancreatic [beta]-cell dysfunction. Cells respond to ER stress by the unfolded protein response (UPR), which increases protein folding capacity and causes degradation of misfolded proteins. Using a pancreatic [beta]-cell model of induced misfolded proinsulin expression (proinsulin-C96Y tagged with GFP) we discovered that one of the most highly induced genes was stromal cell-derived factor 2 like 1 (SDF2L1). SDF2L1 is an ER localized soluble protein with an as yet unknown function. In this thesis I examined the potential role of SDF2L1 in pancreatic [beta]-cells in ER stress conditions.
Other link(s)
hdl.handle.net
tspace.library.utoronto.ca
Subject
SDF2L1.
ER stress.
0487.
0719.