Item – Theses Canada

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OCLC number
1032956332
Link(s) to full text
LAC copy
LAC copy
Author
Bernick, Joshua Hart.
Title
A Preclinical Assessment of Lithium to Enhance Fracture Healing.
Degree
MAST -- University of Toronto, 2013
Publisher
Toronto : University of Toronto, 2013.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
Delayed or impaired bone healing occurs in 5-10% of all fractures, yet cost effective solutions to enhance the healing process are limited. Lithium, a current treatment for bipolar disorder, is not clinically indicated for use in fracture management, but has been reported to positively influence bone biology. The objective of this study was to identify lithium administration parameters that maximize bone healing in a preclinical, rodent femur fracture model. Using a three factor, two level, design of experiments (DOE) approach, bone healing was assessed through mechanical testing and CT-image analysis. Significant improvements in healing were found at a low dose, later onset, longer duration treatment combination, with onset identified as the most influential parameter. The positive results from this DOE screening focuses the optimization phase towards further investigation of the onset component of treatment, and forms a crucial foundation for future studies evaluating the role of lithium in fracture healing.
Other link(s)
hdl.handle.net
tspace.library.utoronto.ca
Subject
Fracture Healing.
Lithium.
Wnt Pathway.
Design of Experiments.
Biomechanics.
Torsion Testing.
Microcomputed Topography.
Stereology.
Preclinical.
Femur.
0541.