Item – Theses Canada

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OCLC number
1032941987
Link(s) to full text
LAC copy
LAC copy
Author
Durk, Robert Matthew.
Title
Role of the Vitamin D Receptor in MDR1P-glycoprotein Regulation at the Blood-brain Barrier.
Degree
(Ph. D.)--University of Toronto, 2014.
Publisher
Toronto : University of Toronto, 2014.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
The blood-brain barrier (BBB) presents a major obstacle for drugs targeting the brain. Drugs that are small or lipophilic enough can penetrate the physical barrier, but are commonly effluxed back into the blood by transporters that are expressed at the luminal membrane, notably P-glycoprotein (P-gp). It has also been shown that amyloid-[beta] (A[beta]), a key player in Alzheimer's disease, is a P-gp substrate. We demonstrate that P-gp levels and function are upregulated upon activation by the vitamin D receptor (VDR) via its natural ligand 1[alpha],25-dihydroxyvitamin D
Other link(s)
tspace.library.utoronto.ca
hdl.handle.net
Subject
blood-brain barrier.
P-glycoprotein.
regulation.
vitamin D receptor.