Item – Theses Canada

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OCLC number
1032936568
Link(s) to full text
LAC copy
LAC copy
Author
Boulos, Mark Iskander.
Title
Exploring the Relationship of Sleep-related Movement Disorders with Cerebrovascular Disease.
Degree
MAST -- University of Toronto, 2014
Publisher
Toronto : University of Toronto, 2014.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
INTRODUCTION: The association of Sleep-Related Movement Disorders (SRMDs) such as Restless Legs Syndrome (RLS) and Periodic Limb Movements (PLMs) with cerebrovascular disease is underexplored. Emerging evidence links them to vascular disease, for which white matter hyperintensities (WMHs) are a well-recognized biomarker. METHODS: We conducted a cross-sectional hospital-based observational study in which high-risk TIA and minor stroke patients were assessed for vascular risk factors, WMHs and polysomnography-determined sleep variables. RESULTS: Ninety-seven patients were enrolled, of whom 44 completed polysomnography. Twenty-five percent had RLS, which was associated with lower quality of life. Independent of the effect of classical vascular risk factors, PLMs (but not RLS) were associated with WMHs on linear regression analyses (p=0.016). CONCLUSIONS: SRMDs are prevalent after minor stroke/TIA. RLS is associated with poor quality of life, while PLMs are associated with WMHs. Whether PLMs are implicated in the pathogenesis of WMHs or whether WMHs exacerbate PLMs remains uncertain.
Other link(s)
hdl.handle.net
tspace.library.utoronto.ca
tspace.library.utoronto.ca
tspace.library.utoronto.ca
tspace.library.utoronto.ca
Subject
cerebrovascular disease.
stroke.
transient ischemic attack.
periodic limb movements.
Restless Legs Syndrome.
neuroimaging.
sleep.
white matter hyperintensities.
MRI.
0564.