Item – Theses Canada

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OCLC number
1032907718
Link(s) to full text
LAC copy
LAC copy
Author
Rovinski, Randal.
Title
The Relationship between Very Long Chain Plasma Ceramides and Anxiety in Coronary Artery Disease.
Degree
MAST -- University of Toronto, 2013
Publisher
Toronto : University of Toronto, 2013.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
Anxiety is a highly prevalent comorbidity in coronary artery disease (CAD) and confers increased risk of subsequent cardiac events and mortality. However, biological mechanisms of this relationship are not well understood. Ceramides are sphingolipids involved in inflammatory signaling and cell viability in the periphery and nervous system, and are implicated in pathophysiological mechanisms associated with anxiety. This study aimed to investigate relationships between plasma ceramide concentrations and anxiety symptomology as assessed by the Spielberger State-Trait Anxiety Inventory trait subscale (STAI-T) in CAD patients with linear regressions. High performance liquid chromatography coupled electrospray ionization tandem mass spectrometry was used to assay sphingolipid species. Plasma C22:0 ceramide ([beta]=-0.232, p=0.018) concentrations and 8 other species of sphingolipids (SM18:0, SM20:1, C18:0, C20:0, C18:1, DHC22:0, LacC22:0, LacC24:1) were negatively correlated with STAI-T score when controlling for gender, BMI, and CES-D. Findings suggest specific sphingolipids to be potential markers for anxiety severity in CAD.
Other link(s)
hdl.handle.net
tspace.library.utoronto.ca
Subject
anxiety.
coronary artery disease.
ceramide.
biological markers.
mood.
inflammation.
sphingolipid.
0419.