Item – Theses Canada

OCLC number
1019488410
Link(s) to full text
LAC copy
Author
Tunnicliffe, Jasmine Maria.
Title
The Link Between Coffee and Type 2 Diabetes :chlorogenic Acid and Intestinal Glucose Absorption.
Degree
M. Sc. -- University of Calgary, 2011
Publisher
Ottawa :Library and Archives Canada = Bibliothèque et Archives Canada,2012.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
<?Pub Inc> Coffee ingestion is associated with reduced risk of type 2 diabetes (T2D). Coffee is the primary source of chlorogenic acid (CGA). The aim of this project was to examine the mechanisms by which CGA regulate blood glucose and insulin response, an impairment of which can lead to T2D. Sprague-Dawley (n=12) rats underwent a meal tolerance test with and without CGA in a cross-over design to measure blood glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). CGA ingestion significantly attenuated blood glucose both and GIP response while no difference was noted with GLP-1 or insulin. Secondly, the NCI-H716 human colon cell line was incubated with CGA or its main metabolites (caffeic acid and ferulic acid); results showed no effect on GLP-1 release. This work shows that CGA can reduce postprandial blood glucose rise and has potential for development into an anti-diabetic agent.
ISBN
9780494752449
0494752440