Item – Theses Canada

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OCLC number
1019479322
Link(s) to full text
LAC copy
Author
Binnington, Matthew.
Title
CYP2A6 and CYP2B6 Genetic Variation, and Tobacco Use Behaviours and Biomarkers in Alaska Natives.
Degree
M.S. -- University of Toronto, 2011
Publisher
Ottawa : Library and Archives Canada = Bibliothèque et Archives Canada, 2012.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
<?Pub Inc> The impact of 'CYP2A6' and 'CYP2B6' genetic variation on nicotine metabolism, tobacco use behaviours, and nicotine biomarkers was investigated in a group of Alaska Natives ('n' = 400). ' CYP2A6' and 'CYP2B6' allele frequencies were unique and associations of CYP2A6 genotype and CYP2A6 activity (plasma and urine ' trans' 3'-hydroxycotinine/cotinine (3HC/COT) ratios) were robust. Notably, this population possessed a more rapid rate of CYP2A6 activity (higher plasma 3HC/COT) when compared to 'CYP2A6' wild-type individuals in other ethnic groups (ANOVA 'P' < 0.001). Also demonstrated was a significant difference in urine total nicotine equivalents by CYP2A6 activity median split ('t'-test P < 0.01), the first evidence of nicotine titration by CYP2A6 activity within a light smoking population. Overall, this population possessed a distinctive pattern of 'CYP2A6 ' and 'CYP2B6' variant frequencies and a faster rate of nicotine metabolism, which may in part explain higher levels of tobacco use prevalence and tobacco-related disease risk.
ISBN
9780494823521
0494823526