Item – Theses Canada

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OCLC number
1019475825
Link(s) to full text
LAC copy
Author
Wright, Kathryn Jean.
Title
Endurance exercise training attenuates fibrosis and collagen cross-linking in myocardium of aged rats.
Degree
M.S. -- University of Calgary, 2012
Publisher
Ottawa : Library and Archives Canada = Bibliothèque et Archives Canada, 2013.
Description
1 online resource
Notes
Includes bibliographical references.
Abstract
<?Pub Inc> It has been postulated that endurance exercise training (ET) could attenuate the age-related increase in fibrosis and collagen cross-linking in the myocardium of the heart, which is thought to be a cause of the age-related decline in diastolic function. Fisher 344 x Brown Norway F1 rats underwent ET from late middle age into senescence. Genes for collagen synthesis, degradation, enzymatic cross-linking, and the renin-angiotensinaldosterone system were assessed by polymerase chain reaction. Matrix metalloproteinase (MMP) activity was assessed and collagen cross-linking was determined indirectly by immunohistochemical staining for advanced glycation end-products. Tissue inhibitor of matrix metalloproteinase-1 (TIMP1) gene expression and MMP activity increased with age but with no ET effect. ET attenuated the age-related increase in fibrosis and collagen cross-linking, while increasing survival rate. This could have attenuated the age-related decline in myocardial compliance which could have helped attenuate the decrease in diastolic function generally seen with aging.
ISBN
9780494911600
0494911603
9780494911600