Item – Theses Canada

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OCLC number
1017533015
Link(s) to full text
LAC copy
Author
Bacchus, Ravi,1971-
Title
The effects of stress on [beta]1 thyroid hormone receptor immunoreactivity in brain.
Degree
M. Sc. -- University of Toronto, 1999
Publisher
Ottawa : National Library of Canada = Bibliothèque nationale du Canada, [2001]
Description
1 microfiche
Notes
Includes bibliographical references.
Abstract
The goal of this project was to determine whether stressful conditions could produce changes in [beta]1-like immunoreactivity in rat brain. Three stress models were used. First, social isolation was examined, but produced no changes in [beta]1-like immunoreactivity in the brain regions examined. Second, uncontrollable foot shock, a model of depression and a more intense form of stress, was utilized but also suggested a lack of plasticity in the [beta]1 receptor subtype. Third, learned helplessness was used and resulted in increased [beta]1-like receptor immunoreactivity in the locus coeruleus, cerebellum and superior olivary nucleus. The upregulation of the [beta]1 receptor subtype in the locus coeruleus is a potentially important finding, since it is a major adrenergic centre and a target for the actions of tricyclic antidepressants (TCAs) suggesting that changes in [beta]1 like immunoreactivity are not a result of stress per se, but may be associated with differential, depressive-type responses to stress.
ISBN
0612461386
9780612461383