Item – Theses Canada

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OCLC number
1007717141
Link(s) to full text
LAC copy
LAC copy
Author
Bulloch, Jane Ellen,1982-
Title
Acute respiratory and systemic responses to diesel exhaust particle exposure.
Degree
M. Sc. -- Laurentian University, 2011
Publisher
Ottawa : Library and Archives Canada = Bibliothèque et Archives Canada, [2011]
Description
1 microfiche
Notes
Author's name on microfiche is spelled Jane Ellen Bullock.
Includes bibliographical references.
Abstract
<?Pub Inc> For decades, epidemiological studies have shown increases in morbidity and mortality associated with exposure to particulate air pollution. Increasingly, experimental data is unravelling the precise mechanisms through which particulate matter exerts its effects on the aggravation of respiratory and cardiovascular conditions. We undertook a series of 'in vivo' studies to measure the acute effects of diesel exhaust particles (DEP) on pulmonary and systemic inflammation, by administering DEP to Balb/c mice intranasally. We observed significant neutrophil and antigen presenting cell infiltration into the lungs after exposure to DEP. Significant increases in CD54 expression suggest that DEP had a maturation effect on dendritic cells (DC). Increased production of GM-CSF in association with DEP treatment was also shown. Systemic inflammation was demonstrated by a significant increase in serum amyloid A (SAA) in association with DEP treatment; interestingly, no concomitant increases in fibrinogen or sP-selectin were observed. These results indicate that significant pulmonary inflammation and partial induction of the systemic response is linked to exposure to DEP. Pulmonary inflammation and DC maturation are implicated in aggravation of allergic respiratory symptoms and morbidity; increased SAA in serum is a known marker of cardiovascular risk. While further study is needed, these results contribute to our current understanding of the impact of inhaled pollutants on respiratory and cardiovascular health.
ISBN
9780494718735
0494718730