Item – Theses Canada

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OCLC number
1007021109
Link(s) to full text
LAC copy
LAC copy
Author
Mansi, James A.,1970-
Title
The dynamics of the stress response in the rat brain : an examination of how stress can modulate the expression and activity of the main stress related hormones.
Degree
Ph. D. -- Université Laval, 2001
Publisher
Ottawa : National Library of Canada = Bibliothèque nationale du Canada, [2001]
Description
4 microfiches
Notes
Includes bibliographical references.
Abstract
The ensuing chapters shall focus on four fundamental hypothesis which, when analysed together will expand and broaden our outlook and interpretation of the stress response. Specifically, the major aims were: (1) to investigate the effects of chronic stress exposure on cardiovascular and sympathoadrenal responses induced by a novel stress in the borderline hypertensive and Wistar Kyoto rat strains; (2) to examine the effects of the neurogenic stress of immobilisation on a series of functional indices for neural activity in the PVN of borderline hypertensive rats compared to their paired normotensive control, the Wistar Kyoto rats; (3) to validate the existence of an ultra-short positive feedback loop within the PVN through which CRF may modulate its own biosynthesis as well as that of its receptors; (4) to examine how enkephalin-containing perikarya from brain stem nuclei, known to send projections to the PVN, are modulated in response to different stress paradigms.
ISBN
0612579425
9780612579422