Item – Theses Canada

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OCLC number
1006759258
Link(s) to full text
LAC copy
LAC copy
Author
Wang, Hui,1970-
Title
Effect of the drilling fluids IPAR and NEODENE on biotransforming enzymes in rats.
Degree
M. Sc. -- Memorial University of Newfoundland, 2000
Publisher
Ottawa : National Library of Canada = Bibliothèque nationale du Canada, [2002]
Description
2 microfiches
Notes
Includes bibliographical references.
Abstract
Drilling fluid, as a rich source of petroleum compounds, is a potential environmental pollutant after disposal. The effects of two drilling fluids: IPAR and NEODENE on biotransforming enzyme activities in rats were examined following administration of 1 to 4 doses (i.p. 1ml/dose). These activities measured included hepatic and renal mixed function oxidases, glutathione S-transferases, and peroxisomal enzymes. Overall, IPAR and NEODENE have the potential to cause metabolic dysfunction. A significant weight loss was observed after NEODENE administration in every treated group. The inhibition of xenobiotic metabolizing enzyme activities would lead to a slower elimination of NEODENE which may contribute to its toxicity. However, the alteration of enzyme activity is not dose-dependent. Therefore, these endpoints as biomarkers of drilling fluid exposure need to be further examined. (Abstract shortened by UMI.)
ISBN
0612624382
9780612624382