Item – Theses Canada

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OCLC number
1006743304
Link(s) to full text
LAC copy
LAC copy
Author
Bray, Peter William,1970-
Title
Allograft microvascular epiphyseal plate transplants with short-term immunosuppression.
Degree
M. Sc. -- University of Toronto, 1999
Publisher
Ottawa : National Library of Canada = Bibliothèque nationale du Canada, [2001]
Description
2 microfiches
Notes
Includes bibliographical references.
Abstract
Current immunosuppressants are too toxic for long-term use in the context of allograft epiphyseal plate transplantation. Epiphyseal plates possess unique characteristics, however, that may permit long-term survival with only a short-term course of immunosuppression. A model for the free allograft microvascular transplantation of the rabbit proximal tibial epiphyseal plate was developed and validated. Transplants included the minimal amount of adjacent bone compatible with preservation of the epiphyseal plate vascular supply. This model was then used to assess the epiphyseal plate viability with a short-term immunosuppression regimen. Immunosuppression was provided by an initial 6-week course of continuous Cyclosporine therapy. Histologic and immunohistochemical evaluation of epiphyseal plate viability was performed four weeks after withdrawal. Epiphyseal plate grafts with bone contact were viable according to all outcome measures. Grafts without bone contact, however, were non-viable and showed evidence of advanced rejection. These results suggest that viability of allograft epiphyseal plates can be preserved following withdrawal of short-term immunosuppression provided the graft design and recipient site allow for adequate graft neovascularization.
ISBN
0612458512
9780612458512