Item – Theses Canada

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OCLC number
1006664382
Author
White, Lynn H.(Lynn Heather),1966-
Title
Task-specific effects of glucose and stress on memory.
Degree
Ph. D. -- McGill University, 1997
Publisher
Ottawa : National Library of Canada = Bibliothèque nationale du Canada, [2000]
Description
3 microfiches
Notes
Includes bibliographical references.
Abstract
The peripheral and central mechanisms mediating the modulatory effects of glucose and acute stress in rats were investigated using two versions of an appetitive win-stay task. Post-training injections of glucose, but not fructose, enhanced retention on the closed maze task. Acquisition of this task was found to be impaired by lesions of the fimbria-fornix (FF). Further experiments showed that while the celiac ganglion and the FF normally participate in suppressing the memory-enhancing effect of an acute stressor, neither structure is involved in mediating the effect of glucose on memory. Post-training injections of glucose, but not fructose, enhanced retention on the open maze task. Although acquisition of this task was not affected by FF lesions, both the celiac ganglion and the FF participate in mediating the memory-enhancing effect of glucose. Together, the results suggest that the peripheral and central mechanisms studied here are both substance- and task-specific. The modulatory effects of different types of stress, and the issue of whether task acquisition and memory modulation are anatomically distinct are discussed.
ISBN
061244628X
9780612446281